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Equine Metabolic Syndrome and Equine Cushings Disease Equine Metabolic Syndrome (EMS) and Equine Cushings Disease (ECD) are common disorders of the endocrine system of horses/ponies that manifest with a variety of clinical signs. They are of importance because they can cause considerable discomfort to your horse/pony, especially if the horse/pony develops laminitis (founder) – a very painful disease. Early detection and management can help improve the quality of life of your horse or pony.